Setup was pretty easy. The video card has an S-Video output and two DVI-I outputs. They thoughtfully included a DVI-to-VGA adapter, though I will probably get a DVI-to-HDMI cable and try that out, too. I was able to run Windows in 1920x1080 resolution right away.
I can get 12 PokerStars tables on the screen at the same time, though with a bit of vertical overlap. The overlap is less if I switch to normal fonts instead of large.
Sid Meier's "Railroads!" runs at full HD and looks pretty good. My other games will only go up to 1280x1024. (SimCity has a 1600x1200 mode listed but the TV can't do that--- vertical resolution too high. It doesn't offer any horizontal resolution between 1280 and 1920, actually.)
I haven't figured out how I want to hook up the sound yet. The Shuttle has a digital audio output but my amplifier is ancient. It also includes five speaker outputs for surround sound and a headphone jack in front. My plan is to start by running the headphone jack through an RCA converter and plug it into the amplifier (although I could run a headphone cable to the back of the TV, too, which includes an audio input to go along with the VGA input.) timprov suggested that we could turn things around and have the computer serve as CD player, DVD player, and amplifier, and feed it digital audio from the TV. I'm not yet ready to turn that much control of my living room over to Microsoft.
The project in progress is downloading some FC6 ISOs; I will set up a Linux VM and try to install my Linux games as well.